Sunday, December 29, 2019

organic chemistry - RO (alkoxide) as a leaving group


Why is RO (alkoxide) a better leaving group than OH, despite RO being more unstable due to the electron donating effect of the alkyl group on RO?


I read that the suitability of leaving groups is dependent also on their nucleophilicity, as good nucleophiles will tend to re-attack the molecule it left from. To what extent is this true?





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