Saturday, April 20, 2019

experimental chemistry - How to perform solvent extraction of a solid


Suppose I have a solid compound from which I want to extract a target chemical I know is soluble in acetone. So I crush and mix the compound in acetone, dissolving the target and suspending the detritus.




  1. What are methods for filtering the detritus from the solution? I have frequently seen coffee filters used for this purpose. Are commercial coffee filters considered "lab-grade?" Or, suppose that the target chemical has some affinity for cellulose, what alternatives exist for suspension filtration?





  2. Now, having the target chemical in solution I assume it is easiest to extract it by evaporating the acetone. Is there a process for this that doesn't leave any of the target stuck to the glass or whatever was containing the solution?





Answer




What are methods for filtering the detritus from the solution? I have frequently seen coffee filters used for this purpose. Are commercial coffee filters considered "lab-grade?" Or, suppose that the target chemical has some affinity for cellulose, what alternatives exist for suspension filtration?



The method that comes to mind for this task is a Soxhlet extraction. Commercial coffee filters are not "lab-grade." Soxhlet extraction thimbles are available in cellulose.




Now, having the target chemical in solution I assume it is easiest to extract it by evaporating the acetone. Is there a process for this that doesn't leave any of the target stuck to the glass or whatever was containing the solution?



Yes - rotary evaporation, in conjunction with Soxhlet extraction.


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